Read e-book online Advances in Virus Research, Vol. 63 PDF

By Karl Maramorosch, Aaron J. Shatkin

ISBN-10: 0120398656

ISBN-13: 9780120398652

The Advances in Virus examine sequence covers a various diversity of in-depth stories offering a precious evaluation of the present box of virology. This eclectic quantity comprises six experiences protecting subject matters in terms of plant viruses, evolution of viruses with hosts and mobile acceptance through viruses.

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2001). This region overlaps the stabilizing region of the CPD attachment receptor-binding domain by only seven amino acids, indicating that it could target an additional receptor, possibly as part of a receptor complex. , 2003) as is a chimeric DHBV carrying the supposed host-range determinant at aa 22–37 from HHBV (Dallmeier and Nassal, unpublished data). Hence, the question regarding the molecular determinants of the hepadnaviral host range is certainly not yet finally settled. B. Experimental In Vivo Infection The natural route of DHBV infection in the duck is from the dam to the egg via the bloodstream.

TM2, which serves as a signal sequence for translocation of the C-terminal region of the polyprotein into the ER lumen, also has a translocation stop signal between residues 80 and 99, which anchors the protein in the lipid bilayer. The 32 URSULA SCHULTZ ET AL. , 2000). The S protein is the major structural component of the particle: it determines envelope curvature and drives the budding and secretion of viral and subviral particles. While the roles of the various minor L species have not been determined, the L protein has crucial functions in assembly and entry that are based on the multiple membrane topologies it adopts.

It is generally accepted that clearance of intracellular pathogens DUCK HEPATITIS B VIRUS 47 requires the destruction of infected cells by major histocompatibility complex (MHC) class I-restricted CD8þ CTLs that kill their target cells via Perforin- or Fas-dependent mechanisms (Chisari and Ferrari, 1995). , 1987a,b). That these cytokines can potentially cure viral infections without killing the infected cell has only been appreciated in the last few years. Experimental approaches to study the influence of cytokines on HBV pathogenesis and clearance of the infection have been hampered because the host range of HBV is restricted to man and chimpanzees.

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Advances in Virus Research, Vol. 63 by Karl Maramorosch, Aaron J. Shatkin

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