Download PDF by Wenfei Jin: Admixture Dynamics, Natural Selection and Diseases in

By Wenfei Jin

ISBN-10: 9401774064

ISBN-13: 9789401774062

ISBN-10: 9401774080

ISBN-13: 9789401774086

ISBN-10: 9535105884

ISBN-13: 9789535105886

In this thesis, Dr. Jin provides the distribution of ancestral chromosomal segments within the admixed genome, which may give you the info had to discover inhabitants admixture dynamics. the writer derives exact inhabitants histories of African american citizens and Mexicans utilizing genome-wide unmarried nucleotide polymorphisms (SNPs) information. Mapping the genetic history allows the examine of normal choice within the admixed inhabitants, and the writer identifies the indications of choice in African americans in view that their African ancestors left for the US. He extra demonstrates that a few of the choice signs have been linked to African American-specific high-risk ailments resembling prostate melanoma and high blood pressure, suggesting a massive function those disease-related genes may have performed in adapting to their new setting. finally, the writer finds the complexity of common choice in shaping human susceptibility to affliction. The thesis considerably advances our figuring out of the hot inhabitants admixture, model to neighborhood atmosphere and its healthiness implications.

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Extra resources for Admixture Dynamics, Natural Selection and Diseases in Admixed Populations

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A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet. 2004;74:1001–13. Tian C, et al. A genomewide single-nucleotide-polymorphism panel with high ancestry information for African American admixture mapping. Am J Hum Genet. 2006;79:640–9. Xu S, et al. Dissecting linkage disequilibrium in african-american genomes: roles of markers and individuals. Mol Biol Evol. 2007;24:2049–58. Pfaff CL, Kittles RA, Shriver MD. Adjusting for population structure in admixed populations.

Durbin RM, et al. A map of human genome variation from population-scale sequencing. Nature. 2010;467:1061–73. Luo L, Boerwinkle E, Xiong M. Association studies for next-generation sequencing. Genome Res. 2011;21:1099–108. Gorlov IP, Gorlova OY, Sunyaev SR, Spitz MR, Amos CI. Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms. Am J Hum Genet. 2008;82:100–12. Li B, Leal SM. Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data.

Patterson N, et al. Methods for high-density admixture mapping of disease genes. Am J Hum Genet. 2004;74:979–1000. Jin W, Li R, Zhou Y, Xu S. Distribution of ancestral chromosomal segments in admixed genomes and its implications for inferring population history and admixture mapping. Eur J Hum Genet. 2014;22:930–7. Chapter 3 Exploring Population Admixture Dynamics via Distribution of LACS Abstract By comparing the distribution of LACS in admixed population with those of various hypothesized scenarios, we could find the scenario with distribution of LACS best fit the observed distribution.

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Admixture Dynamics, Natural Selection and Diseases in Admixed Populations by Wenfei Jin

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